Connection

Announcement

You can now add alternative names! Click here to add other names that you've published under.

Search Results to Peter Crooks

This is a "connection" page, showing the details of why an item matched the keywords from your search.

Search Results

Crooks, Peter

One or more keywords matched the following items that are connected to Crooks, Peter

Item Type	Name
Concept	Bacterial Proteins
Concept	Carrier Proteins
Concept	Cytoskeletal Proteins
Concept	DNA-Binding Proteins
Concept	Membrane Proteins
Concept	Protein Disulfide Reductase (Glutathione)
Concept	Protein Subunits
Concept	Proteins
Concept	Protein Conformation
Concept	GTP-Binding Proteins
Concept	BRCA1 Protein
Concept	Recombinant Proteins
Concept	Mitogen-Activated Protein Kinase 9
Concept	Proto-Oncogene Proteins p21(ras)
Concept	Vesicular Monoamine Transport Proteins
Concept	Mitochondrial Proteins
Concept	Vesicular Biogenic Amine Transport Proteins
Concept	Protein Binding
Concept	Serotonin Plasma Membrane Transport Proteins
Concept	Protein Transport
Concept	Tumor Suppressor Protein p53
Concept	BH3 Interacting Domain Death Agonist Protein
Concept	bcl-X Protein
Concept	Plasma Membrane Neurotransmitter Transport Proteins
Concept	Neurotransmitter Transport Proteins
Concept	Mutant Chimeric Proteins
Concept	Nerve Tissue Proteins
Concept	Norepinephrine Plasma Membrane Transport Proteins
Concept	Viral Nonstructural Proteins
Concept	Protein Biosynthesis
Concept	Intracellular Signaling Peptides and Proteins
Concept	Protein Structure, Secondary
Concept	I-kappa B Proteins
Concept	Membrane Transport Proteins
Concept	Dopamine Plasma Membrane Transport Proteins
Concept	bcl-2-Associated X Protein
Concept	Protein Structure, Tertiary
Concept	Neoplasm Proteins
Concept	Proto-Oncogene Proteins c-bcl-2
Concept	Oncogene Protein v-akt
Concept	Proto-Oncogene Proteins c-akt
Concept	Nuclear Proteins
Concept	Recombinant Fusion Proteins
Academic Article	Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.
Academic Article	Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier.
Academic Article	NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Academic Article	The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion.
Academic Article	N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2() and alpha7() neuronal nicotinic acetylcholine receptors.
Academic Article	meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.
Academic Article	The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins.
Academic Article	Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras.
Academic Article	Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity.
Academic Article	Spectrophotometric and steady-state kinetic analysis of the biosynthetic arginine decarboxylase of Yersinia pestis utilizing arginine analogues as inhibitors and alternative substrates.
Academic Article	Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
Academic Article	Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.
Academic Article	Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter.
Academic Article	Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter.
Academic Article	3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter.
Academic Article	N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity.
Academic Article	The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery.
Academic Article	An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
Academic Article	Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.
Academic Article	Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
Academic Article	Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter.
Academic Article	Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier.
Academic Article	The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.
Academic Article	The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.
Academic Article	Synthesis of novel isoluminol probes and their use in rapid bacterial assays.
Academic Article	Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.
Academic Article	The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery.
Academic Article	Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat.
Academic Article	Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.
Academic Article	Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.
Academic Article	Vesicular monoamine transporter 2: role as a novel target for drug development.
Academic Article	Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.
Academic Article	A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells.
Academic Article	Quinlobelane: a water-soluble lobelane analogue and inhibitor of VMAT2.
Academic Article	Phenyl ring-substituted lobelane analogs: inhibition of [?H]dopamine uptake at the vesicular monoamine transporter-2.
Academic Article	Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.
Academic Article	Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
Academic Article	The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.
Academic Article	Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.
Academic Article	The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.
Academic Article	Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions.
Academic Article	Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.
Academic Article	Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor.
Academic Article	Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.
Academic Article	Lobelane analogues as novel ligands for the vesicular monoamine transporter-2.
Academic Article	bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.
Academic Article	The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats.
Academic Article	Stereocontrolled synthesis and pharmacological evaluation of cis-2,6-diphenethyl-1-azabicyclo[2.2.2]octanes as lobelane analogues.
Academic Article	KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells.
Academic Article	Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats.
Academic Article	Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization.
Academic Article	The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib.
Academic Article	The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
Academic Article	GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine.
Academic Article	Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).
Academic Article	Computational neural network analysis of the affinity of lobeline and tetrabenazine analogs for the vesicular monoamine transporter-2.
Academic Article	The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats.
Academic Article	Effects of VMAT2 inhibitors lobeline and GZ-793A on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo.
Academic Article	Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
Academic Article	The novel small molecule a9a10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic.
Academic Article	Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents.
Academic Article	Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.
Academic Article	Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.
Academic Article	Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.
Academic Article	Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1.
Academic Article	A water-soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFkappaB and generating reactive oxygen species.
Academic Article	1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1).
Academic Article	1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2.
Academic Article	Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.
Academic Article	Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2.
Academic Article	Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.
Academic Article	Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay.
Academic Article	Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer.
Academic Article	GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2.
Academic Article	Succinamide derivatives of melampomagnolide B and their anti-cancer activities.
Academic Article	Persistent Activation of NF-?B in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
Academic Article	Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development.
Academic Article	DMAPT inhibits NF-?B activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo.
Academic Article	Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2.
Academic Article	New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders.
Academic Article	Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats.
Academic Article	N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
Grant	Early Events in Alzheimer Pathogenesis
Academic Article	Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein-Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with ?9-Tetrahydrocannabinol and JWH-018.
Academic Article	GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine.
Academic Article	Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases.
Academic Article	A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease.
Academic Article	Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of A? Self-Aggregation and Metal Chelation-Induced A? Aggregation.
Academic Article	Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands.
Academic Article	Structural modeling of GSK3? implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs.
Academic Article	Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC.
Academic Article	Antitumor properties of novel sesquiterpene lactone analogs as NF?B inhibitors that bind to the IKK? ubiquitin-like domain (ULD).
Academic Article	Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.
Academic Article	High flux novel polymeric membrane for renal applications.

Search Criteria

GTP Binding Proteins